Papers And Originals

Measurement of Plasma Digoxin Concentration by Radioimmunoassay

Br Med J 1970; 3 doi: (Published 22 August 1970) Cite this as: Br Med J 1970;3:427
  1. D. C. Evered,
  2. C. Chapman,
  3. C. J. Hayter


    A rapid, sensitive, and precise method for measuring the plasma digoxin concentration has been developed with the radioimmunoassay technique. Seventy patients receiving digoxin were shown to have plasma digoxin concentrations between 0·4 and 5 ng./ml. Preliminary studies show that though there is a positive correlation between total daily dose and the plasma digoxin concentration, the relationship is not close, and a relatively wide range of plasma digoxin concentrations appear to be consistent with effective digitalization.