Preliminary Communications

Phenytoin Tolerance Tests

Br Med J 1970; 3 doi: https://doi.org/10.1136/bmj.3.5716.203 (Published 25 July 1970) Cite this as: Br Med J 1970;3:203
  1. Anthony J. Handley

    Abstract

    Oral and intravenous phenytoin tolerance tests showed distinctive biphasic curves with a fall in plasma phenytoin to very low levels after an initial peak and a rise to a secondary peak one to four hours later. It is suggested that this pattern should be borne in mind when intravenous phenytoin is being used, as in the control of status epilepticus or cardiac arrhythmias.

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