Severe Depressive Mood Changes Following Slow-release Intramuscular Fluphenazine InjectionBr Med J 1969; 3 doi: https://doi.org/10.1136/bmj.3.5670.564 (Published 06 September 1969) Cite this as: Br Med J 1969;3:564
- R. de Alarcon,
- M. W. P. Carney
Sixteen patients in whom schizophrenia was initially diagnosed and who were treated with fluphenazine enanthate or decanoate developed severe depression for a short period after the injection. In five cases this depression is thought to have been responsible for suicide. In 8 out of 10 cases the depression responded to electroplexy (E.C.T.). It is recommended that patients who are treated with fluphenazine should be carefully supervised.