Inhibition by Aspirin of Release of Antiheparin Activity from Human PlateletsBr Med J 1969; 3 doi: https://doi.org/10.1136/bmj.3.5667.394 (Published 16 August 1969) Cite this as: Br Med J 1969;3:394
- A. H. Youssef,
- P. Barkhan
Both in vitro and in vivo, aspirin inhibited the adenosine diphosphate and collagen-induced release of platelet factor 4 (antiheparin factor). The release induced by adrenaline and thrombin was not affected. The in-vivo effect in normal persons lasted for at least three days. Platelet uptake of acetyl-14C-aspirin was significantly greater than that of carboxyl-14C-aspirin.