Preliminary Communications

Adrenergic Innervation of Bowel in Hirschsprung's Disease

Br Med J 1969; 3 doi: https://doi.org/10.1136/bmj.3.5666.330-a (Published 09 August 1969) Cite this as: Br Med J 1969;3:330
  1. B. J. Gannon,
  2. Helen R. Noblet,
  3. G. Burnstock

    Abstract

    The adrenergic innervation of normal and aganglionic regions of bowel from patients with Hirschsprung's disease was investigated by a fluorescent histochemical technique. In normal bowel the adrenergic nerves end about intramural ganglion cells. In aganglionic bowel the adrenergic nerves form a dense varicose plexus in both muscularis externa and muscularis mucosae. It is suggested that the cause of megacolon in Hirschsprung's disease is due to a lack of nervous pathways controlling the intrinsic reflexes, which is probably congenital in origin.

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