Iron Metabolism in the Anaemia of Chronic Renal Failure. Effects of Dialysis and of Pareuteral IronBr Med J 1969; 3 doi: https://doi.org/10.1136/bmj.3.5664.206 (Published 26 July 1969) Cite this as: Br Med J 1969;3:206
- R. A. Carter,
- J. B. Hawkins,
- B. H. B. Robinson
Serial studies of iron transport in patients on maintenance dialysis showed normal or raised values in almost all subjects and a transient increase soon after the start of dialysis in three. These patients, who were seldom or never transfused, had low serum iron levels and normal iron-binding capacity with low saturation. Iron transport was substantially increased by parenteral iron-dextran treatment. Tracer studies showed good iron utilization, with transport to the marrow rather than to the liver. In these circumstances iron therapy is safe and beneficial, and a useful rise in red cell mass was shown to result from it. The packed cell volume was found to be a valid index of red cell mass in these patients. Red cell loss in the dialysers was insufficient to account for the observed reduction in red cell survival.