Papers And Originals

Liver Transplantation in Man—IV, Haemorrhage and Thrombosis

Br Med J 1969; 3 doi: (Published 05 July 1969) Cite this as: Br Med J 1969;3:20
  1. P. T. Flute,
  2. M. O. Rake,
  3. Roger Williams,
  4. M. J. Seaman,
  5. R. Y. Calne


    Blood coagulation and fibrinolytic factors have been measured in 13 patients treated by liver transplantation. During operation intravascular coagulation and fibrinolysis were increased, but seldom to a degree which would cause abnormal bleeding. Measurement of the catabolism of radioactive fibrinogen showed that increased intravascular coagulation continued for long periods after the operation. Despite secondarily increased fibrinolysis, there was a high incidence of thrombosis. Treatment with anticoagulants or with fibrinolysis inhibitors may be valuable in these patients.