Papers And Originals

Long-term Anticoagulant Therapy after Myocardial Infarction in Women

Br Med J 1968; 3 doi: https://doi.org/10.1136/bmj.3.5618.571 (Published 07 September 1968) Cite this as: Br Med J 1968;3:571
  1. Chr. F. Borchgrevink,
  2. Chr. Bjerkelund,
  3. A. M. Abrahamsen,
  4. G. Bay,
  5. P. Borgen,
  6. B. Grande,
  7. I. Helle,
  8. H. Kjörstad,
  9. A. M. Petersen,
  10. T. Rörvik,
  11. R. Thorsen,
  12. A. Ödegaard

    Abstract

    A multicentre trial from five medical departments in Oslo has been carried out to determine the value in women patients of one year's long-term anticoagulant therapy. Follow-up long-term laboratory control and anticoagulant dosage were performed at one centre (the Rikshospitalet). One hundred and fifty-nine patients were assigned randomly into two similar well-matched groups (control and treatment). Dosage was controlled by Thrombotest, aiming at 10–20% levels, and 50% of the tests were less than 14%. Compared with the control group, the treatment group showed a significant reduction in mortality and in reinfarction rate. No serious bleeding complications occurred. It is concluded that women benefit as much as men from long-term anticoagulant therapy.

    Footnotes

    • * From Medical Departments VII, VIII, and IX, Ullevål Sykehus; Medical Department A, Aker Sykehus; Krohgstötten Sykehus; and Institute for Thrombosis Research, Rikshospitalet, Oslo, Norway.