Preliminary Communications

Reversal of Folate Malabsorption in Tropical and Non-tropical Sprue by Calf Jejunum

Br Med J 1968; 3 doi: (Published 24 August 1968) Cite this as: Br Med J 1968;3:472
  1. H. Baker,
  2. O. Frank,
  3. H. Ziffer,
  4. S. Feingold,
  5. A. A. Cintron-Rivera


    In eight patients with folic acid malabsorption the malabsorption was reversed only when a combination of either 250 mg. of lyophilized human jejunal juice or 5 g. of lyophilized calf jejunum with 5 mg. of synthetic folic acid was fed; calf liver was ineffective. The factors in calf jejunum that re-established folic acid absorption were heat-stable and did not form polyglutamyl folates on previous incubation with folic acid.

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