Research Article

Different lengths of treatment with co-trimoxazole for acute uncomplicated urinary tract infections in women.

BMJ 1989; 299 doi: https://doi.org/10.1136/bmj.299.6711.1319 (Published 25 November 1989) Cite this as: BMJ 1989;299:1319
  1. T. A. Trienekens,
  2. E. E. Stobberingh,
  3. R. A. Winkens,
  4. A. W. Houben
  1. Department of Medical Microbiology, University of Limburg, Maastricht, The Netherlands.

    Abstract

    STUDY OBJECTIVE--To compare three days' and seven days' treatment with co-trimoxazole in women with acute dysuria, strangury, and urinary frequency or urgency. DESIGN--Randomised double blind placebo controlled trial. SETTING--General practices in the south east of The Netherlands. PATIENTS--327 Non-pregnant female patients aged 12 to 65. INTERVENTION--161 Women were allocated to three days' treatment (co-trimoxazole 960 mg twice a day), and 166 women were allocated to seven days' treatment (co-trimoxazole 960 mg twice a day). MAIN OUTCOME MEASURE--Resolution of symptoms at one, two, and six weeks. RESULTS--The rates for resolution of symptoms were not significantly different between the two groups. Cumulative rates of recurrence after three days' and seven days' treatment were 31/139 (22%) and 23/151 (15%) respectively six weeks after entry (p = 0.16). Adverse effects occurred in a quarter of women given three days' treatment compared with a third of women receiving seven days' treatment (p = 0.29). In only two patients did adverse effects necessitate stopping treatment. CONCLUSIONS--Three days of co-trimoxazole seems to be as effective as a seven days' course for treating acute urinary tract infection in non-pregnant women.