Research Article

Poor sulphoxidation ability in patients with food sensitivity.

BMJ 1988; 297 doi: (Published 09 July 1988) Cite this as: BMJ 1988;297:105
  1. G. K. Scadding,
  2. R. Ayesh,
  3. J. Brostoff,
  4. S. C. Mitchell,
  5. R. H. Waring,
  6. R. L. Smith
  1. Department of Immunology, Middlesex Hospital Medical School, London.


    Patients with well defined reactions to foods were examined for their ability to carry out both sulphur and carbon oxidation reactions by using carbocisteine and debrisoquine as probe compounds. The proportion of poor sulphoxidisers (58 of 74) was significantly greater than that of a previously determined normal control population (67 of 200; p less than 0.005). The proportion of poor carbon oxidisers was not significantly different from the controls. Metabolic defects may play a part in the pathogenesis of adverse reactions to foods.