Research Article

Impact of gestrinone on the course of asymptomatic endometriosis.

Br Med J (Clin Res Ed) 1987; 294 doi: https://doi.org/10.1136/bmj.294.6567.272 (Published 31 January 1987) Cite this as: Br Med J (Clin Res Ed) 1987;294:272
  1. E J Thomas,
  2. I D Cooke

    Abstract

    A new drug, gestrinone, was subjected to the first double blind, randomised placebo controlled trial of any treatment of endometriosis. The disease deteriorated in eight (47%) of the 17 patients prescribed placebo (95% confidence limits 23% and 71%) compared with none of the 18 patients prescribed gestrinone (p = 0.002). There was a difference in elimination of the endometriosis in the gestrinone group compared with placebo but this was not statistically significant (p = 0.057). There was a significant difference in improvement of the disease in the gestrinone group compared with placebo (p = 0.004), confirming that gestrinone is an effective treatment of endometriosis. Endometriosis deteriorates in at least 23% of patients; as it is impossible to predict in whom this will happen, treatment appears to be warranted in all cases.