Low serum selenium concentration and glutathione peroxidase activity in intrahepatic cholestasis of pregnancy.BMJ 1987; 294 doi: http://dx.doi.org/10.1136/bmj.294.6565.150 (Published 17 January 1987) Cite this as: BMJ 1987;294:150
- A Kauppila,
- H Korpela,
- U M Mäkilä,
- E Yrjänheikki
Serum selenium concentrations were found to be significantly lower in women with intrahepatic cholestasis of pregnancy than in women with normal pregnancies during the last trimester of pregnancy and post partum. The activity of the selenoenzyme glutathione peroxidase had a significant positive correlation with selenium concentration and it was also significantly lower in women with the disease. These findings suggest that selenium deficiency and reduced glutathione peroxidase activity are associated with the aetiopathogenesis of intrahepatic cholestasis of pregnancy.