Research Article

Increased incidence of menstrual abnormalities and hysterectomy preceding primary biliary cirrhosis.

Br Med J (Clin Res Ed) 1986; 293 doi: https://doi.org/10.1136/bmj.293.6542.297 (Published 02 August 1986) Cite this as: Br Med J (Clin Res Ed) 1986;293:297
  1. A J Stellon,
  2. R Williams

    Abstract

    A study was performed to assess the incidence of previous hysterectomy and dilatation and curettage among women with primary biliary cirrhosis. In 87 patients with primary biliary cirrhosis hysterectomy or dilatation and curettage had been performed significantly more often than among 100 age matched normal controls and 80 age matched patients with chronic active hepatitis or alcoholic liver disease. Among the 47 patients with primary biliary cirrhosis who had undergone hysterectomy or dilatation and curettage operations had been performed at a mean of 10.7 years and 13.2 years, respectively, before the onset of disease. The main indication for hysterectomy among patients with primary biliary cirrhosis and controls was menorrhagia. These menstrual disorders may be a consequence of high concentrations of oestrogens in patients with primary biliary cirrhosis.