Research Article

Amodiaquine induced agranulocytosis: inhibition of colony growth in bone marrow by antimalarial agents.

Br Med J (Clin Res Ed) 1986; 292 doi: https://doi.org/10.1136/bmj.292.6522.717 (Published 15 March 1986) Cite this as: Br Med J (Clin Res Ed) 1986;292:717
  1. E G Rhodes,
  2. J Ball,
  3. I M Franklin

    Abstract

    Bone marrow was cultured in vitro for colonies of granulocytes and macrophages five months after a patient had recovered from amodiaquine induced agranulocytosis. The addition of amodiaquine, chloroquine, and sulfadoxine to the culture was followed by a dose dependent inhibition of colony growth in the patient's marrow but not in normal control bone marrow. Colony growth was, however, unaffected by proguanil, pyrimethamine, and quinine. These findings show that in vitro marrow culture may have important predictive value in some cases of drug induced agranulocytosis.