Research Article

Renal handling of calcium and sodium in metastatic and non-metastatic malignancy.

Br Med J (Clin Res Ed) 1986; 292 doi: https://doi.org/10.1136/bmj.292.6520.583 (Published 01 March 1986) Cite this as: Br Med J (Clin Res Ed) 1986;292:583
  1. S R Heller,
  2. D J Hosking

    Abstract

    Investigation of the renal handling of calcium and sodium in rehydrated patients with hypercalcaemia associated with malignancy showed enhanced reabsorption of calcium in most cases. This was a feature of both metastatic and non-metastatic malignancy, and in this respect the patients were indistinguishable from patients with primary hyperparathyroidism. As the increased calcium reabsorption was inversely correlated with the rate of excretion of sodium modest salt loading can be used to inhibit this process. This is an important practical aspect of the treatment of patients with this type of hypercalcaemia.