Research Article

Improved survival of patients with homozygous familial hypercholesterolaemia treated with plasma exchange.

Br Med J (Clin Res Ed) 1985; 291 doi: https://doi.org/10.1136/bmj.291.6510.1671 (Published 14 December 1985) Cite this as: Br Med J (Clin Res Ed) 1985;291:1671
  1. G R Thompson,
  2. J P Miller,
  3. J L Breslow

    Abstract

    Plasma exchange was undertaken in five patients with homozygous familial hypercholesterolaemia at intervals of two weeks for a mean of 8.4 years. These patients had survived an average of 5.5 years longer than their five respective homozygous siblings (p = 0.3), each of whom must have had a matching genetic defect but who died untreated. The 37% decrease in peak serum cholesterol concentrations maintained by plasma exchange presumably reduced progression of atherosclerosis in the treated patients and thus lessened their risk of premature death.