Research Article

Treatment of presumed prolactinoma by transsphenoidal operation: early and late results.

Br Med J (Clin Res Ed) 1985; 291 doi: (Published 30 November 1985) Cite this as: Br Med J (Clin Res Ed) 1985;291:1550
  1. J A Thomson,
  2. G M Teasdale,
  3. D Gordon,
  4. D C McCruden,
  5. D L Davies


    Seventy seven patients who were presumed to have a prolactinoma on the basis of biochemical findings underwent transsphenoidal operation between October 1977 and September 1983. Sixty one patients were found to have a microadenoma, and hyperprolactinaemia was cured in 46 of these, amenorrhoea in 39 (80% of those with the symptom), galactorrhoea in 32 (80%), and infertility in 31 (82%). Four of eight patients found to have a macroadenoma were also satisfactorily treated with surgery. Two patients had a lesion other than a prolactinoma, and in six a tumour could not be found at operation; four of these last eight patients had a normal serum prolactin concentration after operation. Recurrent hyperprolactinaemia was rare, occurring in only three patients in the series overall; among the 32 patients followed up for more than five years only two of the 22 whose operation had initially been successful developed recurrent hyperprolactinaemia.