Research Article

Variation in human T lymphotropic virus III (HTLV-III) antibodies in homosexual men: decline before onset of illness related to acquired immune deficiency syndrome (AIDS).

Br Med J (Clin Res Ed) 1985; 291 doi: https://doi.org/10.1136/bmj.291.6501.997 (Published 12 October 1985) Cite this as: Br Med J (Clin Res Ed) 1985;291:997
  1. R J Biggar,
  2. M Melbye,
  3. P Ebbesen,
  4. S Alexander,
  5. J O Nielsen,
  6. P Sarin,
  7. V Faber

    Abstract

    Western blot analysis was used to document the development and changes in human T lymphotropic virus III (HTLV-III) antibody among Danish homosexual men followed longitudinally over three years. Reactivity against p15, p24, and p55 appeared earliest. After seroconversion the antibody concentration fluctuated, but in one instance a steady decline in banding intensity was seen during the 18 months before onset of the acquired immune deficiency syndrome (AIDS) and throughout the remaining eight months of his life.