Research Article

Lack of effect of oral magnesium on high blood pressure: a double blind study.

Br Med J (Clin Res Ed) 1985; 291 doi: https://doi.org/10.1136/bmj.291.6490.235 (Published 27 July 1985) Cite this as: Br Med J (Clin Res Ed) 1985;291:235
  1. F P Cappuccio,
  2. N D Markandu,
  3. G W Beynon,
  4. A C Shore,
  5. B Sampson,
  6. G A MacGregor

    Abstract

    Seventeen unselected patients with mild to moderate essential hypertension and whose average supine blood pressure after two months' observation with no treatment was 154/100 mm Hg were entered into a double blind randomised crossover study of one month's treatment with magnesium aspartate (15 mmol magnesium/day) and treatment with placebo for a further month. This preparation of magnesium was well tolerated and did not cause diarrhoea. Despite a significant increase in plasma magnesium concentration and a significant increase in urinary excretion of magnesium while taking magnesium aspartate there was no fall in blood pressure compared with either treatment with placebo or values before treatment. The results provide no evidence for a role of dietary magnesium in the regulation of high blood pressure and are contrary to recent speculations.