Research Article

Hepatitis B virus DNA in saliva, urine, and seminal fluid of carriers of hepatitis B e antigen.

Br Med J (Clin Res Ed) 1985; 290 doi: https://doi.org/10.1136/bmj.290.6485.1853 (Published 22 June 1985) Cite this as: Br Med J (Clin Res Ed) 1985;290:1853
  1. P Karayiannis,
  2. D M Novick,
  3. A S Lok,
  4. M J Fowler,
  5. J Monjardino,
  6. H C Thomas

    Abstract

    Concentrated samples of saliva, urine, and seminal fluid from 23 men with chronic liver disease who were positive for hepatitis B e antigen were examined for the presence of hepatitis B virus deoxyribonucleic acid (HBV-DNA) by molecular hybridisation. HBV-DNA was detected in saliva from 15 of 17 men (88%), urine from 12 of 22 men (55%), and seminal fluid from 13 of 21 men (62%). The presence of hepatitis B virus in such secretions has important epidemiological implications for heterosexual and homosexual contact.