Research Article

Somatostatin and the dumping syndrome.

Br Med J (Clin Res Ed) 1985; 290 doi: (Published 23 March 1985) Cite this as: Br Med J (Clin Res Ed) 1985;290:886
  1. R G Long,
  2. T E Adrian,
  3. S R Bloom


    Infusion of somatostatin reduced the symptoms of the early dumping syndrome after oral glucose was given and also reduced the associated tachycardia and rise in packed cell volume. It inhibited the secretion of enteroglucagon, neurotensin, and vasoactive intestinal polypeptide, which are raised in patients with the dumping syndrome and may have an aetiological role. It also prevented the reactive hypoglycaemia of late dumping by inhibiting the release of gastric inhibitory polypeptide and insulin. Somatostatin, possibly through its inhibitory effects on hormonal secretion, may have a role in the management of patients with the early and late dumping syndrome.