Research Article

Use of a long acting somatostatin analogue in controlling life threatening ileostomy diarrhoea.

Br Med J (Clin Res Ed) 1984; 289 doi: http://dx.doi.org/10.1136/bmj.289.6451.1027 (Published 20 October 1984) Cite this as: Br Med J (Clin Res Ed) 1984;289:1027
  1. N S Williams,
  2. J C Cooper,
  3. A T Axon,
  4. R F King,
  5. M Barker

    Abstract

    A woman presented with persistent ileostomy diarrhoea unresponsive to conventional drug treatment and necessitating parenteral nutrition. Output was four to six litres of watery fluid per 24 hours while she was receiving oral nutrition and two to three litres when she was starved. Treatment with a long acting analogue of somatostatin (50 micrograms subcutaneously every 12 hours) reduced the ileostomy output to 2.0-2.5 litres/24 hours with an oral diet and the effluent became semiformed. Parenteral fluids could be stopped. Somatostatin may have a role in the treatment of secretory diarrhoea, but prospective controlled trials are necessary.