Research Article

Effect of glycaemic control and duration of disease on overnight albumin excretion in diabetic children.

Br Med J (Clin Res Ed) 1984; 289 doi: http://dx.doi.org/10.1136/bmj.289.6450.957 (Published 13 October 1984) Cite this as: Br Med J (Clin Res Ed) 1984;289:957
  1. D J Rowe,
  2. M Hayward,
  3. H Bagga,
  4. P Betts

    Abstract

    Urine albumin excretion rates were measured in overnight timed samples from diabetic and non-diabetic schoolchildren. The excretion rates in the diabetics were significantly higher than those in the controls and were positively correlated with age, duration of diabetes, and glycaemic control. Diabetic children aged 12 years and older had significantly higher albumin excretion rates than younger diabetic children matched for duration of disease. Among the non-diabetic controls there was no correlation between albumin excretion rate and age and the girls excreted significantly more albumin than the boys. Measurement of the overnight albumin excretion rate may provide a useful early indicator of the progression to clinical proteinuria in diabetes and is free from random variations such as that due to exercise.