Lymphadenopathy and selective IgA deficiency.Br Med J (Clin Res Ed) 1984; 289 doi: https://doi.org/10.1136/bmj.289.6446.646 (Published 15 September 1984) Cite this as: Br Med J (Clin Res Ed) 1984;289:646
- M A French
Four men presented with unexplained lymphadenopathy. Three had a history of recurrent respiratory infections for several years, and two had lymph node or hepatic granulomas. None was noted to have symptoms of immunodeficiency at the time of presentation. In one patient routine direct immunofluorescence study failed to detect IgA, and immunological investigations were therefore conducted in the rest. In all patients the findings were similar and characterised by a severe deficiency of IgA. In the absence of a more serious cause selective IgA deficiency may be enough to explain "idiopathic" lymphadenopathy.