Research Article

Metabolic acidosis induced by carbonic anhydrase inhibitors and salicylates in patients with normal renal function.

Br Med J (Clin Res Ed) 1984; 289 doi: https://doi.org/10.1136/bmj.289.6441.347 (Published 11 August 1984) Cite this as: Br Med J (Clin Res Ed) 1984;289:347
  1. R A Cowan,
  2. G G Hartnell,
  3. C P Lowdell,
  4. I M Baird,
  5. A M Leak

    Abstract

    Two young patients with unimpaired renal and hepatic function were found to have developed metabolic acidosis after treatment for glaucoma and joint pain with a combination of salicylates and carbonic anhydrase inhibitors in normal doses. Carbonic anhydrase inhibitors appear to interact with salicylates to produce serious metabolic acidosis in patients without the predisposing factors generally considered to constitute risks. It is recommended that treatment combining salicylates and carbonic anhydrase inhibitors is either kept to a minimum or avoided.