Research Article
Anti-Jo-1 antibody: a marker for myositis with interstitial lung disease.
Br Med J (Clin Res Ed) 1984; 289 doi: https://doi.org/10.1136/bmj.289.6438.151 (Published 21 July 1984) Cite this as: Br Med J (Clin Res Ed) 1984;289:151
- R M Bernstein,
- S H Morgan,
- J Chapman,
- C C Bunn,
- M B Mathews,
- M Turner-Warwick,
- G R Hughes
Abstract
An autoantibody known as anti-Jo-1 antibody is found in 25% of patients with myositis. Its prevalence in patients with both myositis and cryptogenic fibrosing alveolitis was 68% (13 out of 19 patients), compared with 7.5% in patients with myositis alone (four of 53) and 3% in patients with cryptogenic fibrosing alveolitis alone (two of 62). Anti-Jo-1 antibody may be useful in indicating patients with myositis and cryptogenic fibrosing alveolitis. Raynaud's phenomenon, the sicca syndrome, and mild arthritis are also often part of the syndrome.