Research Article

Effect of aspirin in "aspirin sensitive" patients.

Br Med J (Clin Res Ed) 1984; 288 doi: https://doi.org/10.1136/bmj.288.6419.745 (Published 10 March 1984) Cite this as: Br Med J (Clin Res Ed) 1984;288:745
  1. S I Asad,
  2. D M Kemeny,
  3. L J Youlten,
  4. A W Frankland,
  5. M H Lessof

    Abstract

    Eighteen patients with a history of urticaria or asthma, or both, induced by aspirin were studied before and after provocation of symptoms with aspirin. The plasma prostaglandin F2 alpha concentration, which was characteristically raised before challenge, fell significantly at the time of adverse reactions. Repeated administration of aspirin up to a dose of 650 mg daily induced tolerance in most of the patients, and several developed bronchodilator responses to aspirin. Although median total IgE concentrations may be raised in patients with aspirin sensitivity, it appears likely that pharmacological rather than immunological mechanisms are chiefly responsible for the phenomena of aspirin sensitivity and desensitisation.