Research Article

Erythrocyte choline concentrations and cluster headache.

Br Med J (Clin Res Ed) 1984; 288 doi: (Published 28 January 1984) Cite this as: Br Med J (Clin Res Ed) 1984;288:268
  1. J de Belleroche,
  2. G E Cook,
  3. I Das,
  4. R Joseph,
  5. I Tresidder,
  6. S Rouse,
  7. R Petty,
  8. F C Clifford Rose


    Erythrocyte choline concentrations were measured in patients with cluster headache and age related control subjects. Concentrations were significantly reduced in the patients with headache both during a cluster period and between clusters, being 58% and 55% of the control value, respectively. After two weeks' treatment with lithium, choline concentrations in the patients with cluster headache increased to 78 times the control value (mean 369.2 mumol/l (3840 micrograms/100 ml) compared with 4.7 mumol/l (49 micrograms/100 ml]. The presence of depressed erythrocyte choline concentrations during and between cluster attacks indicates that this may be a predisposing condition which results in a cluster attack only when associated with a trigger factor.