Research Article

Hyposensitisation to wasp venom in six hours.

Br Med J (Clin Res Ed) 1983; 287 doi: https://doi.org/10.1136/bmj.287.6402.1329 (Published 05 November 1983) Cite this as: Br Med J (Clin Res Ed) 1983;287:1329
  1. J C van der Zwan,
  2. J Flinterman,
  3. I G Jankowski,
  4. J A Kerckhaert

    Abstract

    Eleven patients with a history of anaphylaxis, positive reactions to skin tests, and specific IgE antibody to wasp venom underwent hyposensitisation in a six hour procedure. No general reactions occurred. Complement activation and proteinuria could not be shown. The patterns of specific IgE, IgG1, and IgG4 were as described in other procedures--namely, IgE increased sharply and then decreased; IgG1 and IgG4 increased steadily and then decreased--but increase and decrease came earlier. Challenge by a stinging insect at least four weeks after treatment proved complete protection. The skin reactivity two years later showed an unpredictable pattern.