Research Article

Propranolol as a novel, effective spermicide: preliminary findings.

Br Med J (Clin Res Ed) 1983; 287 doi: (Published 29 October 1983) Cite this as: Br Med J (Clin Res Ed) 1983;287:1245
  1. J Zipper,
  2. R G Wheeler,
  3. D M Potts,
  4. M Rivera


    The efficacy and tolerability of 80 mg propranolol tablets as a vaginal contraceptive were studied in 198 fertile women for 11 months. The calculated one year life table pregnancy rate was 3.4/100 women and the Pearl index was 3.9/100 women years. No major adverse effects were encountered. The findings suggested that propranolol is an effective vaginal contraceptive whose failure rate compares favourably with that of other methods of contraception. Further study of propranolol and similar compounds is warranted.