Research Article

Effect of daily oral omeprazole on 24 hour intragastric acidity.

BMJ 1983; 287 doi: http://dx.doi.org/10.1136/bmj.287.6384.12 (Published 02 July 1983) Cite this as: BMJ 1983;287:12
  1. R P Walt,
  2. M D Gomes,
  3. E C Wood,
  4. L H Logan,
  5. R E Pounder

    Abstract

    Twenty four hour intragastric acidity was measured in nine patients with duodenal ulcer before and after one week of treatment with oral omeprazole 30 mg daily, a drug that inhibits gastric secretion by inhibition of parietal cell H+K+ adenosinetriphosphatase (ATPase). Omeprazole virtually eliminated intragastric acidity in all patients: the median 24 hour intragastric pH rose from 1.4 to 5.3 and the mean hourly hydrogen ion activity fell from 38.50 to 1.95 mmol(mEq)/1 (p less than 0.001). This inhibition of 24 hour intragastric acidity is more profound than that previously reported with either cimetidine 1 g daily or ranitidine 300 mg daily.