Research Article

Serum pancreatic lipase activity in cystic fibrosis.

Br Med J (Clin Res Ed) 1983; 286 doi: (Published 28 May 1983) Cite this as: Br Med J (Clin Res Ed) 1983;286:1693
  1. D Junglee,
  2. A Penketh,
  3. A Katrak,
  4. M E Hodson,
  5. J C Batten,
  6. P Dandona


    Patients with cystic fibrosis have been found to have abnormal serum concentrations of immunoreactive trypsin and abnormal activities of pancreatic isoamylase. A study was undertaken to discover whether activity of pancreatic lipase is also altered in cystic fibrosis. Serum from 23 patients with cystic fibrosis was assayed for immunoreactive trypsin and pancreatic lipase. Median serum pancreatic lipase activity was significantly lower in patients with cystic fibrosis than in controls, as was immunoreactive trypsin concentration (p less than 0.0001). Some patients had supranormal lipase concentrations but these were not always associated with absence of malabsorption. Serum pancreatic lipase activity is considerably changed in cystic fibrosis.