Research Article

Maturity onset diabetes of the young is not linked to the insulin gene.

Br Med J (Clin Res Ed) 1983; 286 doi: https://doi.org/10.1136/bmj.286.6365.590 (Published 19 February 1983) Cite this as: Br Med J (Clin Res Ed) 1983;286:590
  1. J I Bell,
  2. J S Wainscoat,
  3. J M Old,
  4. C Chlouverakis,
  5. H Keen,
  6. R C Turner,
  7. D J Weatherall

    Abstract

    Maturity onset diabetes of the young is inherited as an autosomal dominant condition. Two families with the disease were studied to determine whether the inheritance of this type of diabetes was linked to the insulin gene. A cloned insulin gene probe was hybridised to DNA from the family members and the insulin gene on each chromosome identified by a different fragment length polymorphism. The results showed no linkage between the insulin gene and the inheritance of maturity onset diabetes of the young.