Research Article

Failure of renal dopamine response to salt loading in chronic renal disease.

Br Med J (Clin Res Ed) 1983; 286 doi: (Published 12 February 1983) Cite this as: Br Med J (Clin Res Ed) 1983;286:503
  1. I F Casson,
  2. M R Lee,
  3. A M Brownjohn,
  4. F M Parsons,
  5. A M Davison,
  6. E J Will,
  7. A D Clayden


    Eight patients with chronic glomerulonephritis and five age-matched normal volunteers were given additional sodium chloride by mouth under conditions of metabolic balance. Whereas in the normal volunteers plasma renin activity was suppressed and urinary excretion of free dopamine increased, in the patients dopamine was not mobilised and plasma renin activity was not completely suppressed. Abnormal retention of sodium and water in glomerulonephritis may be due partly to a failure to mobilise dopamine in the kidney. Specific renal dopamine agonists may be natriuretic and hypotensive in chronic glomerulonephritis.