Research Article

Identification of adverse reactions to new drugs. II--How were 18 important adverse reactions discovered and with what delays?

Br Med J (Clin Res Ed) 1983; 286 doi: http://dx.doi.org/10.1136/bmj.286.6361.289 (Published 22 January 1983) Cite this as: Br Med J (Clin Res Ed) 1983;286:289
  1. G R Venning

    Abstract

    The process of discovery of 18 important adverse drug reactions was reviewed. For each adverse reaction the dates were noted of the report which first alerted the medical profession to the suspected reaction, the report which resulted in verification of causality beyond reasonable doubt, and the first regulatory action or warning to the medical profession in Britain by the Committee on the Safety of Medicines.