Research Article

Long-term continuous intraperitoneal insulin treatment in brittle diabetes.

Br Med J (Clin Res Ed) 1983; 286 doi: (Published 22 January 1983) Cite this as: Br Med J (Clin Res Ed) 1983;286:255
  1. G Pozza,
  2. D Spotti,
  3. P Micossi,
  4. M Cristallo,
  5. M Melandri,
  6. P M Piatti,
  7. L D Monti,
  8. A E Pontiroli


    Attempts to achieve a fair metabolic equilibrium in a young woman with brittle diabetes by continuous subcutaneous, intramuscular, and continuous intravenous administration of insulin were unsuccessful. Continuous intraperitoneal administration of insulin through a permanently inserted polyethylene catheter connected to an open-loop peristaltic pump led to an appreciable improvement in mean blood glucose concentration, mean amplitude of glycaemic excursions, and M value and to normalisation of intermediate metabolic products. The peritoneal catheter was well tolerated for over 120 days without appreciable adverse effects. This case suggests that long-term intraperitoneal administration of insulin is a feasible therapeutic approach in the management of brittle diabetes.