Research Article

Increased incidence of malignancy in dermatitis herpetiformis.

Br Med J (Clin Res Ed) 1983; 286 doi: https://doi.org/10.1136/bmj.286.6358.16 (Published 01 January 1983) Cite this as: Br Med J (Clin Res Ed) 1983;286:16
  1. J N Leonard,
  2. W F Tucker,
  3. J S Fry,
  4. C A Coulter,
  5. A W Boylston,
  6. R M McMinn,
  7. G P Haffenden,
  8. A F Swain,
  9. L Fry

    Abstract

    A retrospective study of 109 patients with dermatitis herpetiformis showed that malignant tumours had developed in seven patients, the expected incidence being 2.93, giving a relative risk of 2.38. In three of the seven patients the malignancy was a lymphoma, giving a relative risk of 100 for this tumour (expected incidence 0.03). In six of the seven patients who developed malignancies small-intestinal biopsy specimens were macroscopically abnormal, giving a relative risk of 4.22 in this group, which is similar to that reported in adult coeliac disease. Patients treated with a gluten-free diet appeared to have a reduced risk of developing malignancy compared with those taking a normal diet (relative risk with gluten-free diet 1.01 and with normal diet 3.09). A small subgroup of eight patients with linear IgA dermatitis herpetiformis were also studied: three developed malignant disease and in one the tumour was a lymphoma.