Erythropoietin and renal function in sickle-cell disease.Br Med J (Clin Res Ed) 1982; 285 doi: http://dx.doi.org/10.1136/bmj.285.6356.1686 (Published 11 December 1982) Cite this as: Br Med J (Clin Res Ed) 1982;285:1686
- A G Morgan,
- C A Gruber,
- G R Serjeant
The relation between haemoglobin concentration, creatinine clearance, and the serum concentration of erythropoiesis-stimulating factor were assessed in 31 patients with homozygous sickle-cell disease. Haemoglobin concentrations fell significantly with decreasing creatinine clearance (r = 0.58, p less than 0.001) and were positively correlated with the concentration of erythropoiesis-stimulating factor (r = 0.65, p less than 0.001). These observations suggest that erythropoietin concentration is the factor limiting production of red cells in sickle-cell disease with renal insufficiency and have implications for treatment.