Research Article

Are HLA antigens important in the development of alcohol-induced liver disease?

Br Med J (Clin Res Ed) 1982; 285 doi: http://dx.doi.org/10.1136/bmj.285.6341.533 (Published 21 August 1982) Cite this as: Br Med J (Clin Res Ed) 1982;285:533
  1. R Faizallah,
  2. J C Woodrow,
  3. N K Krasner,
  4. R J Walker,
  5. A I Morris

    Abstract

    The prevalences of 10 HLA-A and 16 HLA-B antigens were determined in 50 patients with alcoholic cirrhosis and 120 alcoholic patients without cirrhosis and compared with those in a control group of 550 healthy subjects from the same geographical area. B40 was absent in the patients with cirrhosis but was found in 18 (15%) of the patients without cirrhosis (p = 0.0087). No other association was noted. It is concluded that there is no good evidence to date of an association between HLA antigen state and susceptibility to alcohol-induced cirrhosis.