Research Article

Atenolol and metoprolol once daily in hypertension.

Br Med J (Clin Res Ed) 1982; 284 doi: https://doi.org/10.1136/bmj.284.6328.1514 (Published 22 May 1982) Cite this as: Br Med J (Clin Res Ed) 1982;284:1514
  1. A K Scott,
  2. J W Rigby,
  3. J Webster,
  4. G M Hawksworth,
  5. J C Petrie,
  6. H G Lovell

    Abstract

    The effect of once-daily dosage of the two most widely prescribed cardioselective beta-adrenoceptor antagonists used to treat hypertension--namely, atenolol and metoprolol--was studied in nine carefully selected hypertensive outpatients. Each patient received atenolol 50 mg/day, atenolol 100 mg/day, metoprolol 100 mg/day, and metoprolol 200 mg/day in a sustained-release formulation (as Lopresor SR) according to a randomised sequence. After three weeks' treatment with each drug given once daily comparisons of the treatments 24 hours after dosing showed no important differences between 50 and 100 mg atenolol/day. Metoprolol, as both the standard and the slow-release formulations, had some limitations in controlling systolic blood pressure and heart rate. These results suggest that the recommendations for the treatment of hypertension with these cardioselective beta-adrenoceptor antagonists should be reconsidered since doses smaller than those recommended are almost as effective and much cheaper.