Research Article

DR antigens and rheumatoid arthritis: a study of two populations.

Br Med J (Clin Res Ed) 1981; 283 doi: (Published 14 November 1981) Cite this as: Br Med J (Clin Res Ed) 1981;283:1287
  1. J C Woodrow,
  2. F E Nichol,
  3. G Zaphiropoulos


    Thr prevalence of HLA-DR antigens was determined in a group of white patients with rheumatoid arthritis, similar patients originating from the Indian subcontinent, and corresponding controls. Rheumatoid arthritis was found to be highly associated with DR4 in the white patients but with DR1 in the Indian patients. These results raise the possibility that the DR antigens themselves do not play a part in increasing susceptibility to rheumatoid arthritis, but the locus for increased susceptibility is probably closely linked to the DR locus.