Research Article

Urea for long-term treatment of syndrome of inappropriate secretion of antidiuretic hormone.

Br Med J (Clin Res Ed) 1981; 283 doi: https://doi.org/10.1136/bmj.283.6299.1081 (Published 24 October 1981) Cite this as: Br Med J (Clin Res Ed) 1981;283:1081
  1. G Decaux,
  2. F Genette

    Abstract

    The efficacy of oral urea in producing a sufficiently high osmotic diuresis was tested in seven patients with the syndrome of inappropriate secretion of antidiuretic hormone. In all patients urea corrected the hyponatraemia despite a normal fluid intake. Five patients were controlled (serum sodium concentration greater than 128 mmol(mEq)/1) with a dose of 30 g urea daily, and two with 60 g daily. The patients who needed 30 g drank 1-2 1 of fluid daily, while those who needed 60 g drank up to 3.1 per day. No major side effects were noted, even after treatment periods of up to 270 days. These findings suggest that urea is a safe and efficacious treatment of the syndrome of inappropriate secretion of antidiuretic hormone.