Research Article

Serum glutamate dehydrogenase as a marker of hepatocyte necrosis in alcoholic liver disease.

Br Med J (Clin Res Ed) 1981; 283 doi: http://dx.doi.org/10.1136/bmj.283.6294.754 (Published 19 September 1981) Cite this as: Br Med J (Clin Res Ed) 1981;283:754
  1. P R Mills,
  2. R J Spooner,
  3. R I Russell,
  4. P Boyle,
  5. R N MacSween

    Abstract

    Serum glutamate dehydrogenase concentration was assessed as a marker of the degree of hepatocyte necrosis found at liver biopsy in 95 patients suspected of having alcoholic liver disease. Although the serum concentration was raised in 54 patients, no relation between it and the severity of hepatocyte necrosis could be established. Glutamate dehydrogenase was therefore not confirmed to be a useful indicator of hepatocyte necrosis in patients with chronic alcoholism.