Research Article

Oral contraceptive steroid plasma concentrations in smokers and non-smokers.

Br Med J (Clin Res Ed) 1981; 282 doi: https://doi.org/10.1136/bmj.282.6279.1829 (Published 06 June 1981) Cite this as: Br Med J (Clin Res Ed) 1981;282:1829
  1. F E Crawford,
  2. D J Back,
  3. M L Orme,
  4. A M Breckenridge

    Abstract

    A study was performed to find out whether the overall rate of metabolism of oral contraceptives is affected by smoking and whether this explains the increased incidence of cardiovascular disease in users of oral contraceptives who smoke. Plasma ethinyloestradiol and norgestrel concentrations in 311 women using oral contraceptives were similar in smokers and non-smokers. The overall rate of metabolism of contraceptive steroids does not therefore seem to be affected by cigarette smoking.