Research Article

Diagnosis of deep vein thrombosis using autologous indium-III-labelled platelets.

Br Med J (Clin Res Ed) 1981; 282 doi: (Published 28 March 1981) Cite this as: Br Med J (Clin Res Ed) 1981;282:1020
  1. A Fenech,
  2. J K Hussey,
  3. F W Smith,
  4. P P Dendy,
  5. B Bennett,
  6. A S Douglas


    Forty-eight patients who had undergone surgical reduction of a fractured neck of femur or in whom deep vein thrombosis was suspected clinically were studied by ascending phlebography and imaging after injection of autologous indium-111-labelled platelets to assess the accuracy and value of the radioisotopic technique in diagnosing deep vein thrombosis. Imaging was performed with a wide-field gammacamera linked with data display facilities. Phlebography showed thrombi in 26 out of 54 limbs examined and a thrombus in the inferior vena cava of one patient; imaging the labelled platelets showed the thrombi in 24 of the 26 limbs and the thrombus in the inferior vena cava. The accumulation of indium-111 at sites corresponding to those at which venous thrombi have been shown phlebographically indicates that this radioisotopic technique is a useful addition to methods already available for the detection of deep vein thrombosis.