Research Article

Plasmatic regulation of vascular prostacyclin in pregnancy.

Br Med J (Clin Res Ed) 1981; 282 doi: (Published 14 February 1981) Cite this as: Br Med J (Clin Res Ed) 1981;282:512
  1. G Remuzzi,
  2. C Zoja,
  3. D Marchesi,
  4. A Schieppati,
  5. G Mecca,
  6. R Misiani,
  7. M B Donati,
  8. G de Gaetano


    Activity of prostacyclin-stimulating factor was measured in six normal, non-pregnant women, six women in early normal pregnancy, six in late normal pregnancy, and six in late pregnancy complicated by severe pre-eclampsia. The activity was lower in the women in late pregnancy than in those in early pregnancy and the controls but was about normal in those with severe pre-eclampsia. These results may be relevant to the physiology of pregnancy and the pathogenesis of pre-eclampsia.