Research Article

Epstein-Barr-virus-carrying lymphoma in a patient with ataxia-telangiectasia.

Br Med J (Clin Res Ed) 1981; 282 doi: https://doi.org/10.1136/bmj.282.6262.425 (Published 07 February 1981) Cite this as: Br Med J (Clin Res Ed) 1981;282:425
  1. A K Saemundsen,
  2. A I Berkel,
  3. W Henle,
  4. G Henle,
  5. M Anvret,
  6. O Sanal,
  7. F Ersoy,
  8. M Cağlar,
  9. G Klein

    Abstract

    An undifferentiated lymphocytic lymphoma of mesenteric lymph nodes occurred in a young boy with ataxia-telangiectasia. Two independent tests, Epstein-Barr virus (EBV)-cRNA/DNA hybridisation and EBV DNA/DNA reassociation kinetic analysis, showed 53 and 68 EBV genome equivalents per cell respectively, which was compatible with an EBV-genome-carrying tumour. Whether this was a polyclonal lymphoproliferation or a monoclonal tumour could not be determined owing to lack of suitable material. The presence of EBV genomes should be sought in lymphomas arising in ataxia-telangiectasia and other immunodeficiencies.