Research Article

Generalised tissue abnormality of aryl hydrocarbon hydroxylase in psoriasis.

Br Med J 1980; 281 doi: https://doi.org/10.1136/bmj.281.6251.1315 (Published 15 November 1980) Cite this as: Br Med J 1980;281:1315
  1. P H Chapman,
  2. P J Kersey,
  3. B Keys,
  4. S Shuster,
  5. M D Rawlins

    Abstract

    Microsomal aryl hydrocarbon hydroxylase (AHH) activity and inducibility were measured in jejunal mucosa, liver, and lesion-free epidermis of patients with psoriasis. In all three tissues AHH activity and inducibility were less than in controls. This demonstration of a generalised enzymatic abnormality in the tissues of patients with psoriasis is in keeping with the suggestion that it may be close to the underlying genetic defect.