Research Article

Effect of treatment of hyperlipidaemia on haemostatic variables.

Br Med J 1980; 281 doi: https://doi.org/10.1136/bmj.281.6246.973 (Published 11 October 1980) Cite this as: Br Med J 1980;281:973
  1. R S Elkeles,
  2. R Chakrabarti,
  3. M Vickers,
  4. Y Stirling,
  5. T W Meade

    Abstract

    The haemostatic function of 11 men with hyperlipidaemia was measured before and after they were treated with a carbohydrate-reduced, fat-modified diet. After treatment, which significantly reduced serum triglyceride and cholesterol concentrations, they showed a significant fall in mean levels of clotting factors VII, VIII, and X and a rise in fibrinolytic activity. These findings suggest that haemostatic function may be important in the pathogenesis of ischaemic heart disease.